Inappropriate translation inhibition and P-body formation cause cold-sensitivity in tryptophan-auxotroph yeast mutants

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• 作者：Lidia Ballester-Tom&aacute ; s^a ; Jose A. Prieto^a ; Paula Alepuz^b ; Asier Gonz&aacute ; lez^c ; Elena Garre^a ; ¹ ; Francisca Randez-Gil^a ; ^{randez@iata.csic.es}
• 关键词：Yeast ; Low temperature ; Polysomes ; Gcn2 pathway ; eIF2α ; Hog1 ; Snf1
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：314-323
• 全文大小：1496 K
• 卷排序：1864

文摘

Cold results in eIF2α phosphorylation and Gcn2-independent polysome disassembly. Loss of TRP1 increases these effects, which correlates with cold sensitivity. Knock-out of GCN2 improves cold growth of trp1 cells. The MAPK Hog1 plays a role in the regulatory mechanism of Gcn2-eIF2α. P-body formation response is required for cold tolerance.