Analysis of IL-10, IL-4 and TNF-α polymorphisms in drug-induced liver injury (DILI) and its outcome

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• 作者：Ketevan Pachkoria ; M. Isabel Lucena ; Esperanza Crespo ; Francisco Ruiz-Cabello ; Susana Lopez-Ortega ; M. Carmen Fern ; ez ; Manuel Romero-Gomez ; Ana Madrazo ; Jose Antonio Durá ; n ; Ana Malcon de Dios ; Yo
• 关键词：Interleukin 10 ; Interleukin 4 ; Tumor Necrosis factor alpha ; Cytokines ; Drugs ; Hepatotoxicity ; Genetic susceptibility ; Single-nucleotide polymorphism ; Outcome
• 刊名：Journal of Hepatology
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：49
• 期：1
• 页码：107-114
• 全文大小：146 K

文摘

This paper develops a simple approach to critical path analysis in a project network with activity times being fuzzy numbers. The idea is based on the linear programming (LP) formulation and fuzzy number ranking method. The fuzzy critical path problem is formulated as an LP model with fuzzy coefficients of the objective function, and then on the basis of properties of linearity and additivity, the Yager’s ranking method is adopted to transform the fuzzy LP formulation to the crisp one which can be solved by using the conventional streamlined solution methods. Consequently, the critical path and total duration time can be obtained from the derived optimal solution. Moreover, in this paper we also define the most critical path and the relative path degree of criticality, which are theoretically sound and easy to use in practice. An example discussed in some previous studies illustrates that the proposed approach is able to find the most critical path, which is proved to be the same as that derived from an exhausted comparison of all possible paths. The proposed approach is very simple to apply, and it is not require knowing the explicit form of the membership functions of the fuzzy activity times.