Zonated quantification of steatosis in an entire mouse liver
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- 作者：Lars Ole Schwena ; ole.schwen@mevis.fraunhofer.de" class="auth_mail" title="E-mail the corresponding author ; André ; Homeyera ; andre.homeyer@mevis.fraunhofer.de" class="auth_mail" title="E-mail the corresponding author ; Michael Schwiera ; b ; michael.schwier@mevis.fraunhofer.de" class="auth_mail" title="E-mail the corresponding author ; Uta Dahmenc ; uta.dahmen@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author ; Olaf Dirschd ; olaf.dirsch@googlemail.com" class="auth_mail" title="E-mail the corresponding author ; Arne Schenke ; f ; arne.schenk.ext@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Lars Kuepfere ; g ; lars.kuepfer@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Tobias Preussera ; b ; tobias.preusser@mevis.fraunhofer.de" class="auth_mail" title="E-mail the corresponding author ; Andrea Schenka ; andrea.schenk@mevis.fraunhofer.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CV ; central vein ; DXM ; dextromethorphan ; EvG ; Elastica-van Gieson ; GS ; glutamine synthetase ; HE ; hematoxylin & eosin ; PF ; portal field ; PK ; pharmacokinetics
- 刊名：Computers in Biology and Medicine
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：108-118
- 全文大小：3791 K
文摘
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A new spatial quantification shows heterogeneity of liver biomarkers on two scales.
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Steatosis was assessed in histological serial sections covering an entire mouse liver.
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The steatosis is distributed periportally with a notable variation across the organ.
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Steatosis distributions influence results of a whole-body pharmacokinetics simulation.
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This quantification can complement visual evaluation of histological images.