Investigating motor initiation and inhibition deficits in patients with Parkinson’s disease and freezing of gait using a virtual reality paradigm
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- 作者：Matthew J. Georgiadesa ; mgeo9053@uni.sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Moran Gilata ; moran.gilat@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Kaylena A. Ehgoetz Martensa ; kaylena.ehgoetzmartens@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Courtney C. Waltona ; courtney.walton@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Patrick G. Bissettb ; pbissett@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; James M. Shinea ; b ; macshine@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Simon J.G. Lewisa ; simonl@med.usyd.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANCOVA ; analysis of covariance ; ANOVA ; analysis of variance ; APA ; anticipatory postural adjustment ; DBS ; deep brain stimulation ; DDE ; Dopamine Dose Equivalence ; EEG ; electroencephalography ; FOG ; freezing of gait ; FOG-Q ; Freezing of Gait Questionnaire ; H&Y ; Hoehn and Yahr staging ; MDS-UPDRS ; Movement Disorders Society-Unified Parkinson&rsquo ; s Disease Rating Scale ; mFIL ; modal footstep initiation latency ; mFSL ; modal footstep latency ; MMSE ; Mini-Mental State Examination ; PD ; Parkinson&rsquo ; s dis
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 November 2016
- 年：2016
- 卷：337
- 期：Complete
- 页码：153-162
- 全文大小：504 K
文摘
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Impaired motor initiation and inhibition is common with freezing of gait in PD.
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These impairments are explored with a virtual reality task.
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Freezers experienced slower footstep initiation and more frequent start hesitation.
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Freezers took longer to execute motor inhibition with increased frequency of stop failures.
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Cues requiring additional cognitive processing exacerbated stopping impairments.