Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer
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- 作者：Kenneth K.W. Toa ; kennethto@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author ; W.W. Leungb ; Simon S.M. Ngb ; simonng@surgery.cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABCG2 ; ATP-binding cassette sub-family G member 2 transporter ; CRC ; colorectal cancer ; FTC ; fumitremorgin ; HuR ; ELAV-like protein 1 or human antigen R ; MDR ; multidrug resistance ; PhA ; pheophorbide A ; 3&prime ; UTR ; 3&prime ; untranslated region ; 5-FU ; 5-fluorouracil
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：338
- 期：2
- 页码：222-231
- 全文大小：1130 K
文摘
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The RNA binding protein HuR binds to ABCG2 3′UTR and stabilize the transporter.
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Resistant tumors from colorectal cancer patients overexpress ABCG2.
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MicroRNAs, HuR and ABCG2 3′UTR length coordinately regulate ABCG2 overexpression.
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HuR antagonists disrupt HuR–ABCG2 interaction and reduce ABCG2 overexpression.