Click-binol-phosphoric acid catalysts in intramolecular enantioselective oxidative CH-bond functionalization

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• 作者：Sebastian Stockerl^a ; Daniel Gutié ; rrez^a ; Olga Garcí ; a Mancheñ ; o^a ; ^b ; ^{olga.garcia-mancheno@ur.de}
• 关键词：CH functionalization ; Oxidation ; Organocatalysis ; Enantioselective ; Heterocycles
• 刊名：Journal of Molecular Catalysis A: Chemical
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：426
• 期：part_PB
• 页码：572-585
• 全文大小：1928 K
• 卷排序：426

文摘

Synthesis of a new family of C2-symmetric triazole-phosphoric acid catalysts. Intramolecular asymmetric CH bond functionalization of N-aryl substituted tetrahydroisoquinolines. Important effects of the triazoles and the regiomeric structures for optimal enantioselectivity. π–π vs. cooperative π–π and triazole-substrate interactions.