Measurement of human CYP1A2 induction by inhalation exposure to benzo(a)pyrene based on in vivo isotope breath method
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- 作者：Xiaoli Duana ; duan_jasmine@126.com" class="auth_mail" title="E-mail the corresponding author ; Guofeng Shenb ; Hongbiao Yangc ; George Lambertd ; Fusheng Weie ; Junfeng (Jim) Zhangf ; g ; junfeng.zhang@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytochrome P450 1A2 ; Benzo(a)pyrene (BaP) ; Exposure biomarker ; Caffeine Breath Test (CBT)
- 刊名：Environmental Pollution
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：208
- 期：part_PB
- 页码：506-511
- 全文大小：331 K
文摘
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Hypothesis on whether high BaP inhalation exposure can induce CYP1A2 activity.
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Insignificant change in CYP1A2 induction under high BaP inhalation exposure.
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A significantly positive correlation between dietary BaP and CYP1A2 induction.
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Hepatic CYP1A2 induction level was not effected by inhaled BaP but altered by ingestion of BaP.