DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions

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• 作者：Ana Laura Cavatorta^a ; Alejandra Di Gregorio^b ; Marina Bugnon Valdano^a ; Federico Marziali^a ; Mariela Cabral^b ; Hebe Bottai^c ; Jorge Cittadini^b ; Ana Lia Nocito^d ; Daniela Gardiol^a ; ^{gardiol@ibr-conicet.gov.ar}
• 关键词：DLG1 ; human Discs large ; HPV ; Human papillomavirus ; MAGUKs ; membrane-associated guanylate kinase homologues ; PDZ ; PSD-95/DLG/ZO-1 domains ; LSIL ; low-grade squamous intraepithelial lesions ; HSIL ; high-grade squamous intraepithelial lesions ; CIN ; cervical intraepithelial neoplasia ; IHC ; immunohistochemistry ; PAP ; Papanicolaou ; MAGI-2 ; WW and PDZ domain containing protein 2
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：65-69
• 全文大小：1935 K
• 卷排序：102

文摘

There is a significant association between the expression pattern of DLG1 and evolution of LSIL. Fisher Test (p < 0.00001). LSIL patients with a DLG1 pattern similar to normal tissues rarely progress and would benefit from less intensive follow-up.