Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence
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- 作者：Ö ; zlem Akilli Ö ; ztü ; rk1 ; Hubert Pakula1 ; Jolanta Chmielowiec1 ; 4 ; Jingjing Qi1 ; Simone Stein1 ; Linxiang Lan1 ; Yoshiteru Sasaki2 ; Klaus Rajewsky3 ; Walter Birchmeier1 ; wbirch@mdc-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：13
- 期：3
- 页码：561-572
- 全文大小：6774 K
文摘
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Scaffold adaptor Gab1 controls catagen, the destructive phase of the hair cycle
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Gab1 requires Grb2 and Shp2 binding sites and acts via Mapk signaling
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Early stem cells need Gab1 to maintain quiescence at catagen entry
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Gab1 is essential in the establishment of adult stem cells of the bulge