Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor
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- 作者：Paola Maccionia ; Irene Lorraia ; Mauro A.M. Caraib ; Antonella Rivac ; Paolo Morazzonic ; Claudia Mugnainid ; Federico Corellid ; Gian Luigi Gessaa ; Giancarlo Colomboa ; colomb@unica.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Saikosaponin A ; Bupleurum falcatum ; GABAB receptor antagonist ; SCH50911 ; Positive allosteric modulator of the GABAB receptor ; GS39783 ; Operant ; oral alcohol self-administration ; Sardinian alcohol-preferring (sP) rats
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：16 May 2016
- 年：2016
- 卷：621
- 期：Complete
- 页码：62-67
- 全文大小：735 K
文摘
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Saikosaponin A is a major ingredient of the medicinal herb, Bupleurum falcatum.
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Saikosaponin A reduced oral alcohol self-administration in alcohol-preferring rats.
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The effect of saikosaponin A was mediated, at least in part, by the GABAB receptor.
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These results extend to alcohol recent literature data on morphine and cocaine.