Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants

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• 作者：Christoph Grü ; ber ; Margriet van Stuijvenberg ; Fabio Mosca ; Guido Moro ; Gaetano Chirico ; Christian P. Braegger ; Josef Riedler ; Gü ; nther Boehm ; Ulrich Wahn ; MIPS 1 Working Group
• 关键词：Oligosaccharides ; atopic dermatitis ; infant ; primary prevention ; prebiotics
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：126
• 期：4
• 页码：791-797
• 全文大小：292 K

文摘

Background

Most infants developing atopic dermatitis have a low risk for atopy. Primary prevention of atopic dermatitis is difficult.

Objective

To assess the effect of supplementation of an infant and follow-on formula with prebiotic and immunoactive oligosaccharides on the occurrence of atopic dermatitis in the first year of life.

Methods

Healthy term infants from 5 European countries with low atopy risk were recruited before the age of 8 weeks, either having started with formula feeding or being on full breast-feeding (breast-feeding group). Formula-fed infants were randomized to feeding with a regular formula containing a specific mixture of neutral oligosaccharides and pectin-derived acidic oligosaccharides (prebiotic formula group) or regular formula without oligosaccharides (control formula group).

Results

A total of 414 infants were randomized to the prebiotic group and 416 infants to the control group. A total of 300 infants were followed in the breast-feeding group. Up to the first birthday, atopic dermatitis occurred in significantly fewer infants from the prebiotic group (5.7 % ) than from the control group (9.7 % ; P = .04). The cumulative incidence of atopic dermatitis in the prebiotic group was in the low range of the breast-feeding group (7.3 % ). In a Cox regression model, the rate of atopic dermatitis was significantly lower by 44 % in the prebiotic group versus the control group (P = .04). The number needed to prevent 1 case of atopic dermatitis by supplementation of prebiotics was 25 infants.

Conclusion

Formula supplementation with a specific mixture of oligosaccharides was effective as primary prevention of atopic dermatitis in low atopy risk infants.