Adjuvant effects of invariant NKT cell ligand potentiates the innate and adaptive immunity to an inactivated H1N1 swine influenza virus vaccine in pigs
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- 作者：Varun Dwivedia ; Cordelia Manickama ; Santosh Dhakala ; Basavaraj Binjawadagia ; Kang Ouyanga ; b ; Jagadish Hirematha ; c ; Mahesh Khatria ; Jacquelyn Gervay Hagued ; Chang Won Leea ; Gourapura J. Renukaradhyaa ; gourapura.1@osu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pigs ; Swine influenza virus ; iNKT cell ; α-GalCer ; Adjuvant ; Intranasal vaccine
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：186
- 期：Complete
- 页码：157-163
- 全文大小：1606 K
文摘
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Natural killer T (NKT) cell adjuvant α-GalCer potentiates cytokine production in pigs.
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α-GalCer adjuvant increased the virus specific IgA response in the pig respiratory tract.
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α-GalCer adjuvant reduced the SwIV lung viral load in killed SwIV vaccinated pigs.
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NKT cell adjuvant has the potential to augment protective immunity in pigs against flu.