Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8+ T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells
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- 作者：Jordana G. Coelho-dos-Reisa ; b ; jordana.reis@cpqrr.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Jing Huanga ; Tiffany Tsaoa ; Felipe V. Pereiraa ; c ; Ryota Funakoshia ; Hiroko Nakajimad ; Haruo Sugiyamae ; Moriya Tsujia ; mtsuji@adarc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adjuvant ; Glycolipid ; NKT cells ; CD1d ; TLR4 ; Malaria vaccine ; Cancer vaccine ; WT-1 ; Circumsporozoite protein ; Memory-like effector NKT cells
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：168
- 期：Complete
- 页码：6-15
- 全文大小：1629 K
文摘
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7DW8-5, α-GalCer analog, and MPLA, a TLR4 agonist, have a combined adjuvant effect.
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Co-injection of 7DW8-5 with MPLA augments peptide-specific CD8 + T-cell response.
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7DW8-5 and MPLA together enhance protective immunity against malaria and cancer.
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Co-injection of 7DW8-5 with MPLA induces activation of memory-like effector NKT cells.