Controversies Concerning the Antiphospholipid Syndrome in Obstetrics

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• 作者：Dulce Marí ; a Albertina Camarena Cabrera ; ^{dulce.camarena@inper.mx} ; Claudia Rodriguez-Jaimes ; Sandra Acevedo-Gallegos ; Juan Manuel Gallardo-Gaona ; Berenice Velazquez-Torres ; José ; Antonio Ramí ; rez-Calvo
• 关键词：Antiphospholipid antibody syndrome ; Obstetric antiphospholipid syndrome ; Seronegative antiphospholipid syndrome ; Antiphospholipid antibodies ; Adverse perinatal outcome
• 刊名：Reumatología Clínica (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：13
• 期：1
• 页码：30-36
• 全文大小：525 K
• 卷排序：13

文摘

Antiphospholipid antibody syndrome is a non-inflammatory autoimmune disease characterized by recurrent thrombotic events and/or obstetric complications associated with the presence of circulating antiphospholipid antibodies (anticardiolipin antibodies, anti-β2 glycoprotein-I antibodies, and/or lupus anticoagulant).Antiphospholipid antibodies are a heterogeneous group of autoantibodies associated with recurrent miscarriage, stillbirth, fetal growth restriction and premature birth. The diversity of the features of the proposed placental antiphospholipid antibodies fingerprint suggests that several disease processes may occur in the placentae of women with antiphospholipid antibody syndrome in the form of immune responses: inflammatory events, complement activation, angiogenic imbalance and, less commonly, thrombosis and infarction. Because of the disparity between clinical and laboratory criteria, and the impact on perinatal outcome in patients starting treatment, we reviewed the aspects of antiphospholipid antibody syndrome related to obstetric complications and seronegative antiphospholipid antibody syndrome, and their treatment in obstetrics.