Changes in neural circuitry associated with depression at pre-clinical, pre-motor and early motor phases of Parkinson's disease

详细信息    查看全文

• 作者：Janina Borgonovo^a ; ^b ; ^c ; Camilo Allende-Castro^a ; ^b ; ^c ; Almudena Laliena^a ; ^b ; Né ; stor Guerrero^a ; ^b ; Herná ; n Silva^d ; Miguel L. Concha^a ; ^b ; ^c ; ^{mconcha@med.uchile.cl}
• 关键词：Parkinson ; Depression ; Pre-clinical ; Pre-motor ; Early motor stage ; Limbic loop ; Basal ganglia
• 刊名：Parkinsonism & Related Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：35
• 期：Complete
• 页码：17-24
• 全文大小：693 K
• 卷排序：35

文摘

Depression can appear before the onset of motor symptoms in Parkinson's Disease. Defects in the substantia nigra, basal ganglia and limbic structures are observed in the pre-clinical phase. Monoaminergic disfunction associates with emotional disorders in the early motor phase. We propose that the limbic loop of the basal ganglia and the lateral habenula play key roles in the early genesis of depression in PD. A better understanding of depression might facilitate the early diagnosis of Parkinson's disease.