Controlling absence seizures by tuning activation level of the thalamus and striatum

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• 作者：Bing Hu ; ^{hubingst@mail.hzau.edu.cn} ; ^{hubingshuxue@163.com} ; Shun Chen ; Hongmei Chi ; Jin Chen ; Peipei Yuan ; Huihui Lai ; Wangyuan Dong
• 关键词：Spike-and-slow wave discharges ; Basal ganglia-thalamocortical network ; Activation level ; Deep brain stimulation
• 刊名：Chaos, Solitons & Fractals
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：65-76
• 全文大小：1993 K
• 卷排序：95

文摘

In this paper, we use a basal ganglia-corticothalamic model (BGCT) to study control effect of the absence epilepsy seizure. It is shown that the seizure state can be well controlled by tuning activation level of the thalamic reticular nucleus (TRN), specific relay nuclei (SRN), striatal D1 neurons and striatal D2 neurons. And then, one type of deep brain stimulation voltage employed on SRN, we find that seizure activities can also be controlled by tuning the period (P) and the duration of effective current (D) in a period into some appropriate ranges. So, we infer that the thalamic and striatal tissue may become effective target regions in clinical treatment of epilepsy in the future.