Cisplatin-induced neuropathic pain is mediated by upregulation of N-type voltage-gated calcium channels in dorsal root ganglion neurons

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• 作者：Markus Leo^a ; Linda-Isabell Schmitt^a ; Martin Erkel^a ; Margarita Melnikova^b ; Jü ; rgen Thomale^b ; Tim Hagenacker^a ; ^{tim.hagenacker@uk-essen.de}
• 关键词：Neuropathic pain ; Polyneuropathy ; Cisplatin ; Voltage-gated calcium channels ; Dorsal root ganglion ; Conotoxin
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：288
• 期：Complete
• 页码：62-74
• 全文大小：1924 K
• 卷排序：288

文摘

Cisplatin upregulates N-type channels in sensory neurons N-type channel inhibition prevents neuropathic pain in rats. Signaling of N-type channel modulation involves PKC and CaMKII.