Aberrant hypomethylated STAT3 was identified as a biomarker of chronic benzene poisoning through integrating DNA methylation and mRNA expression data
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- 作者：Jing Yang1 ; Wenlin Bai1 ; Piye Niu ; Lin Tian ; gaoai0980@163.com" class="auth_mail ; Ai Gao ; gaoai0980@163.com" class="auth_mail
- 关键词：Chronic benzene poisoning ; Biomarkers ; DNA methylation ; STAT3
- 刊名：Experimental and Molecular Pathology
- 出版年：June 2014
- 年：2014
- 卷：96
- 期：3
- 页码：346-353
- 全文大小：1471 K
文摘
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Three hypermethylated genes (PRKG1, PARD3 and EPHA8) show concurrent down-regulation of corresponding mRNA.
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Two hypomethylated genes (STAT3 and IFNGR1) reveal the increased expression of corresponding mRNA.
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The aberrant hypomethylated STAT3 might be a potential biomarker of chronic benzene poisoning.