A unified nomenclature for short-chain peptides isolated from scorpion venoms: α-KTx molecular subfamilies

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• 作者：Tytgat ; Jan ; Chandy ; K. George ; Garcia ; Maria L. ; Gutman ; George A. ; Martin-Eauclaire ; Marie-France ; et. al.
• 关键词：Neuroscience ; Pharmacology ; Biochemistry ; Peptide ; Potassium ; Channel ; Scorpion ; Venom ; Toxin
• 刊名：Trends in Pharmacological Sciences
• 出版年：1999
• 出版时间：November 1, 1999
• 年：1999
• 卷：20
• 期：11
• 页码：444-447
• 全文大小：141 K

文摘

Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four families of peptides have been purified from scorpion venom. In this article, the classification of K⁺-channel-blocking peptides belonging to family 2 peptides and comprising 30–40 amino acids linked by three or four disulfide bridges, will be discussed. Evidence is provided for the existence of 12 molecular subfamilies, named α-KTx1–12, containing 49 different peptides. Because of the pharmacological divergence of these peptides, the principle of classification was based on a primary sequence alignment, combined with maximum parsimony and Neighbour-Joining analysis. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0165-6147(99)01398-X Publication Type: Miscellaneous ISSN: 0165-6147 Cited by:

1. Zeng, Xian-Chun; Peng, Fang; Luo, Feng; Zhu, Shun-Yi; Liu, Hui; Li, Wen-Xin,""Molecular cloning and characterization of four scorpion K⁺-toxin-like peptides: A new subfamily of venom peptides (a-KTx14) and genomic analysis of a member¹""Biochimie2001pp. 883-889
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2. Garcia-Valdes, Jesus; Zamudio, Fernando Z.; Toro, Ligia; Possan, Lourival D.,""Slotoxin, aKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between a and a+b (b1 or b4) complexes""FEBS Letters2001pp. 369-373
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5. Zhu, Shun-Yi; Li, Wen-Xin; Zeng, Xian-Chun,""Precursor nucleotide sequence and genomic organization of BmTXKS1, a new scorpion toxin-like peptide from Buthus martensii Karsch""Toxicon2001pp. 1291-1296
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6. Garcia, M.L.; Gao, Ying-Duo; McManus, O.B.; Kaczorowski, G.J.,""Potassium channels: from scorpion venoms to high-resolution structure""Toxicon2001pp. 739-748
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7. Dudina, Ekaterina E.; Korolkova, Yuliya V.; Bocharova, Nataliya E.; Koshelev, Sergey G.; Egorov, Tsezi A.; Huys, Isabelle; Tytgat, Jan; Grishin, Eugene V.,""OsK2, a New Selective Inhibitor of Kv1.2 Potassium Channels Purified from the Venom of the Scorpion Orthochirus scrobiculosus""Biochemical and Biophysical Research Communications2001pp. 841-847
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8. Corona, Miguel; Gurrola, Georgina B.; Merino, Enrique; Cassulini, Rita Restano; Valdez-Cruz, Norma A.; Garcia, Blanca; Ramirez-Dominguez, Martha E.; Coronas, Fredy I.V.; Zamudio, Fernando Z.; Wanke, Enzo; Possani, Lourival D.,""A large number of novel Ergtoxin-like genes and ERG K⁺-channels blocking peptides from scorpions of the genus Centruroides""FEBS Letters2002pp. 121-126
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9. Zeng, Xian-Chun; Wang, San-Xia; Li, Wen-Xin,""Identification of BmKAPi, a novel type of scorpion venom peptide with peculiar disulfide bridge pattern from Buthus martensii Karsch""Toxicon2002pp. 1719-1722
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17. D'Suze, G.; Moncada, S.; Gonzalez, C.; Sevcik, C.; Aguilar, V.; Alagon, A.,""Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion sting""Toxicon2003pp. 367-375
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18. Grottesi, Alessandro; Sansom, Mark S.P.,""Molecular dynamics simulations of a K⁺ channel blocker: Tc1 toxin from Tityus cambridgei""FEBS Letters2003pp. 29-33
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19. Legros, Christian; Bougis, Pierre E.; Martin-Eauclaire, Marie-France,""Characterisation of the genes encoding Aa1 isoforms from the scorpion Androctonus australis""Toxicon2003pp. 115-119
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20. Vacher, Helene; Romi-Lebrun, Regine; Crest, Marcel; Masmejean, Frederique; Bougis, Pierre E.; Darbon, Herve; Martin-Eauclaire, Marie-France,""Functional consequences of deleting the two C-terminal residues of the scorpion toxin BmTX3""BBA - Proteins and Proteomics2003pp. 152-156
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Footnotes:

1. The nucleotide sequence data reported in this paper have been submitted to the EMBL Nucleotide Sequence Database under the accession numbers: AJ277726 (BmKK₁); AJ277727 (BmKK₂); AJ277728 (BmKK₃); AJ277729 (BmKK₄); and AJ277730 (genomic sequence of BmKK₂).