Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy
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- 作者：Ping Yang1 ; Shilong Fu1 ; Zhifei Cao ; Huaidong Liao ; Zihe Huo ; Yanyan Pan ; Gaochuan Zhang ; Aidi Gao ; Quansheng Zhou ; zhouqs@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lymphoma ; Cancer therapy ; ER stress ; Apoptosis ; GRP78 ; DDIT3 ; Oroxin B
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：288
- 期：2
- 页码：269-279
- 全文大小：1733 K
文摘
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Oroxin B selectively induces tumor-suppressive ER stress in B-lymphoma cells.
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Oroxin B significantly prolonged overall survival of lymphoma-xenografted mice.
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Oroxin B effectively exerts anti-lymphoma without obvious toxicity.
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Oroxin B promotes tumor-suppressive DDIT3 and inhibits tumorigenic GRP78.