A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis

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• 作者：Federico Pelisch¹ ; Triin Tammsalu¹ ; Bin Wang¹ ; Ellis G. Jaffray¹ ; Anton Gartner¹ ; Ronald T. Hay¹ ; ² ; ^{r.t.hay@dundee.ac.uk}
• 关键词：SUMO ; PIAS ; GEI-17 ; meiosis ; C. elegans ; SUMO-interaction motif ; kinesin ; spindle ; chromosomes ; CRISPR
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：65
• 期：1
• 页码：66-77
• 全文大小：4691 K
• 卷排序：65

文摘

SUMO conjugates accumulate in the ring complex within the midbivalent during meiosis Ring complex assembly requires active sumoylation The SUMO E3 ligase GEI-17/PIAS sumoylates the chromokinesin KLP-19 in vivo and in vitro Meiotic chromosome congression depends on sumoylation and non-covalent SUMO binding