MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU

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• 作者：Yin Peng^a ; ^f ; ¹ ; Xiaojing Zhang^a ; ^e ; ¹ ; Qiang Ma^a ; ¹ ; Ruibin Yan^b ; Ying Qin^h ; Yanqiu Zhao^b ; Yulan Cheng^c ; Mengting Yang^a ; Qixiang Wang^a ; Xianling Feng^a ; Yong Huang^a ; Weiling Huang^a ; Zhenfu Zhao^a ; Liang Wang^a ; ^e ; Yanjie Wei^g ; Zhendan He^d ; Xinmin Fan^a ; Song Li^b ; Zhe Jin^a ; ^d ; ^e ; ^{zhejin@szu.edu.cn} ; Stephen J. Meltzer^c
• 关键词：miRNA-194 ; SUFU ; Wnt/β-catenin signaling pathway ; Gastric cancer
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：117-127
• 全文大小：2101 K
• 卷排序：385

文摘

miRNA-194 is oncogenic in GC. miRNA-194 activates Wnt/β-catenin signaling pathway. miRNA-194 targets SUFU in human gastric cancer cells. SUFU expression is downregulated and negatively associated with tumor stage in GC.