Human Pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function
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- 作者：Ernest T. Chiveroa ; b ; 1 ; Nirjal Bhattaraia ; c ; James H. McLindena ; c ; Jinhua Xianga ; c ; Jack T. Stapletona ; b ; c ; d ; jack-stapleton@uiowa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HPgV ; GBV-C ; NK cells ; Tyk2 ; Immune modulation
- 刊名：Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：485
- 期：Complete
- 页码：116-127
- 全文大小：3130 K
文摘
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Human Pegivirus (HPgV) was formerly called GB virus C interacts with NK cells.
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HPgV particles inhibited NK cell release of IFN-纬 following IL-12 stimulation.
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A peptide within the HPgV E2 protein was sufficient to inhibit NK cell function.
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This peptide inhibited Tyk2 and STAT 4 activation and tyrosine was required.
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HPgV did not inhibit the cytolytic functions of NK cells.
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