Subclass IgG to motor gangliosides related to infection and clinical course in Guillain–Barré syndrome

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• 作者：Bart C. Jacobs ; Michiaki Koga ; Wouter van Rijs ; Karin Geleijns ; Pieter A. van Doorn ; Hugh J. Willison ; Nobuhiro Yuki
• 关键词：Guillain– ; Barré ; syndrome ; Gangliosides ; IgG subclass ; Campylobacter jejuni ; Haemophilus influenzae ; Lipo-oligosaccharides
• 刊名：Journal of Neuroimmunology
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：194
• 期：1-2
• 页码：181-190
• 全文大小：604 K

文摘

In 176 patients with Guillain–Barré syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG1 antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C. jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome.