Induction of apoptosis by apocarotenoids in B16 melanoma cells through ROS-mediated mitochondrial-dependent pathway
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- 作者：Amrita Anantharaman ; Hridya Hemachandran ; Sankari Mohan ; Dhanoop Manikoth Ayyathan ; Thirumal Kumar D ; George Priya Doss C ; Ramamoorthy Siva ; rsiva77in@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Food colourant ; Bixin ; Norbixin ; Apoptosis ; Cell cycle ; B16 melanoma
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：20
- 期：Complete
- 页码：346-357
- 全文大小：3721 K
文摘
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Apocarotenoids inhibited the cell viability of B16 melanoma.
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Apocarotenoids induced apoptosis through mitochondrial-associated death pathway.
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Apocarotenoids induced cell cycle arrest by downregulation of MITF gene expression.
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Apocarotenoids inhibited anti-apoptotic proteins through hydrophobic interaction.