Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes

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• 作者：Akira Matsuda ; Ulrich Germing ; Itsuro Jinnai ; Kayano Araseki ; Andrea Kuendgen ; Corinna Strupp ; Masako Iwanaga ; Yasushi Miyazaki ; Tomoko Hata ; Masami Bessho ; Norbert Gattermann ; Masao Tomonaga
• 关键词：Myelodysplastic syndromes ; Refractory anemia ; Myelodysplastic syndrome-unclassified ; WHO classification ; FAB classification ; Prognosis
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：34
• 期：8
• 页码：974-980
• 全文大小：433 K

文摘

We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (MDS-U) with pancytopenia in Japanese patients were higher than in German patients (p < 0.001). Refractory cytopenia with multilineage dysplasia patients showed the most unfavorable prognosis in both countries. The higher frequencies of MDS-U with pancytopenia and RCUD in Japanese patients may influence the different clinical characteristics between Japanese and German FAB-RA patients.