Metabolic Syndrome and the Risk of Ischemic Stroke

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• 作者：Nizal Sarrafzadegan ; MD^* ; Mojgan Gharipour ; PhD^&dagger ; ; ^{gharipour@crc.mui.ac.ir} ; Masoumeh Sadeghi ; MD^&dagger ; ; Pouya Nezafati ; MD^&dagger ; ; ^&Dagger ; ; Mohammad Talaie ; PhD^* ; ^§ ; ; Shahram Oveisgharan ; MD^‖ ; ^¶ ; ; Fatemeh Nouri ; MS^* ; Alireza Khosravi ; MD^#
• 关键词：Metabolic syndrome ; stroke ; hazard ; prediction
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：26
• 期：2
• 页码：286-294
• 全文大小：151 K
• 卷排序：26

文摘

Metabolic syndrome (MetS) is recently proposed as a predictor for the occurrence of vascular defects causing ischemic stroke. However, details on the association of MetS with stroke are scare in our region. The present study aimed to assess the predictive value of MetS and its components for stoke among the Iranian population.MethodsA longitudinal population-based study was conducted on adults aged 35 years or older who were living in 3 districts in central part of Iran and followed for 10 years. Stroke was diagnosed using World Health Organization guidelines, and MetS was defined according to the Adult Treatment Panel-III definition.ResultsAmong the 5398 subjects, 2021 suffered from MetS with an incidence of 37.4%. The incidence rates of stroke in those with and without MetS were 2.6% and 1.1%, respectively, with a higher significance in the former group (P = .026). Compared to the controls, participants with stroke exhibited a higher prevalence of some components of MetS including hyperglycemia and hypertension. On Cox proportional hazard analysis, the hazard ratio for a long-term risk of ischemic stroke was 1.37 overall (95% confidence interval: 1.15-1.63, P < .001) in subjects with MetS. Considering different components of MetS, hyperglycemia (hazard ratio = 1.83, P = .011) and hypertension (1.74, P = .019) could effectively predict occurrence of long-term ischemic stroke.ConclusionMetS and its main components can be potent predictors for long-term ischemic stroke. Thus, the focus should be on identification and appropriate control of MetS components to prevent stroke occurrence.