Activation of the estrogen receptor by human serum extracts containing mixtures of perfluorinated alkyl acids from pregnant women
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- 作者：Christian Bjerregaard-Olesen ; Mandana Ghisari ; Eva C. Bonefeld-Jø ; rgensen ; ebj@ph.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; BMI ; body mass index ; CD-FBS ; charcoal-dextran stripped fetal bovine serum ; CV ; co-variance ; DHEAS ; dehydroepiandrosterone sulfate ; DMEM ; Dulbecco's modified Eagle's media ; E1S ; estrone sulfate ; E2 ; 17β-estradiol ; EEQ ; estradiol equivalents ; ER ; estrogen receptor ; HPLC ; high performance liquid chromatography ; IQR ; interquartile range ; KHK ; pooled human female serum control ; LOEC ; lowest observed effect concentration ; LOQ ; limit of quantification ; PFAA ; perfluorinated
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：71-79
- 全文大小：547 K
文摘
The mixture of perfluoroalkyl acids was extracted from 397 human serum samples.
Endogenous sex hormones were removed during extraction.
52% of the perfluoroalkyl acid mixtures agonized the estrogen receptor.
46% of the perfluoroalkyl acid mixtures enhanced the activity of 17β-estradiol.
The xenoestrogenic activity was concentration-dependent.