Molecular cloning and pharmacological characterization of giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor
详细信息 查看全文
- 作者：Zhi-Qiang Wanga ; zqwang@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Wangb ; Lin Shia ; Ji-Tian Chaia ; Xin-Jun Zhanga ; Ya-Xiong Taob ; taoyaxi@auburn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：amMC4R ; giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor ; GPCR ; G protein-coupled receptor ; MC4R ; melanocortin-4 receptor ; MSH ; melanocyte-stimulating hormone ; NDP-MSH ; [Nle4 ; D-Phe7]-α-MSH ; PCR ; polymerase chain reaction ; THIQ ; [(N-[(3R)-1 ; 2 ; 3 ; 4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1 ; 2 ; 4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine ; TMD ; transmembrane domain
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：229
- 期：Complete
- 页码：32-40
- 全文大小：2086 K
文摘
- •
Giant panda MC4R cDNA was cloned and phylogenetic analyses were performed.
- •
Giant panda MC4R pharmacology was studied using four agonists.
- •
Giant panda MC4R has similar pharmacology as human MC4R in ligand binding and signaling assays.