Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity
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- 作者：Mark Nixon1 ; 5 ; 8 ; Randi Stewart-Fitzgibbon1 ; 3 ; 8 ; Jingqi Fu1 ; 6 ; 8 ; Dmitry Akhmedov1 ; Kavitha Rajendran1 ; Maria G. Mendoza-Rodriguez1 ; Yisel A. Rivera-Molina1 ; 7 ; Micah Gibson1 ; Eric D. Berglund4 ; Nicholas J. Justice2 ; 3 ; Rebecca Berdeaux1 ; 2 ; 3 ; Rebecca.berdeaux@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：SIK1 ; Salt inducible kinase ; CRTC ; Gluconeogenesis ; Insulin resistance ; CREB
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：5
- 期：1
- 页码：34-46
- 全文大小：1219 K
文摘
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We report the first conditional SIK1 knockout mouse models.
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Global and muscle-specific SIK1-KO mice are insulin sensitive on HFD.
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Liver- and fat-specific SIK1-KO mice are normoglycemic.
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SIK1 expression increases in skeletal muscle of obese mice.
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SIK1 is a promising therapeutic target to improve insulin sensitivity in obesity.