Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4

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• 作者：Regev-Shoshani ; Gilly ; Shoseyov ; Oded ; Kerem ; Zohar
• 关键词：Resveratrol ; CYP3A4 ; Piceid ; Kinetics ; Cyclosporine ; Polyphenols
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2004
• 出版时间：October 15, 2004
• 年：2004
• 卷：323
• 期：2
• 页码：668-673
• 全文大小：339 K

文摘

Resveratrol, a polyphenol found in red wine, was recently suggested to act as an irreversible, mechanism-based inactivator of cytochrome P450 3A4 (CYP3A4). We found a significant inhibition of human CYP3A4-dependent transformation of cyclosporine by resveratrol, with IC₅₀