Novel ligands for the affinity-chromatographic purification of antibodies

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• 作者：Fassina ; Giorgio ; Ruvo ; Menotti ; Palombo ; Giovanna ; Verdoliva ; Antonio ; Marino ; Maria
• 关键词：Antibodies ; Affinity chromatography ; Combinatorial chemistry ; Molecular design ; Synthetic ligands
• 刊名：Journal of Biochemical and Biophysical Methods
• 出版年：2001
• 出版时间：October 30, 2001
• 年：2001
• 卷：49
• 期：1-3
• 页码：481-490
• 全文大小：69.2 K

文摘

Affinity chromatography represents one of the most powerful fractionation techniques for the large-scale purification of biotechnological products. Despite its potential, the use of this methodology is limited by the availability of specific ligands for each target. Combinatorial chemistry and molecular modeling, often combined, have become interesting and innovative methods for generating novel ligands, tailored to specific biotechnological needs.