Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors

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• 作者：Giovanna Delogu ; Gianni Podda ; Marcella Corda ; Maria Benedetta Fadda ; Antonella Fais ; Benedetta Era
• 关键词：Mushroom tyrosinase ; Tyrosinase inhibitor ; Bis-salicylaldehydes ; Non-competitive inhibitor
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：15 October 2010
• 年：2010
• 卷：20
• 期：20
• 页码：6138-6140
• 全文大小：220 K

文摘

A series of novel bis-salicylaldehydes were synthesised and evaluated as tyrosinase inhibitors using a tyrosinase-dependent l-DOPA oxidation assay. The bis-salicylaldehydes exhibited greater inhibitory activity than salicylaldehyde. Our data suggests that these novel compounds may serve as a structural template for the design and development of novel tyrosinase inhibitors.