Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives

详细信息    查看全文

• 作者：Fern ; a P¨¦rez-Cruz ; Silvia Serra ; Giovanna Delogu ; Michel Lapier ; Juan Diego Maya ; Claudio Olea-Azar ; Lourdes Santana ; Eugenio Uriarte
• 关键词：4-Hydroxycoumarins ; Trypanosoma cruzi ; Chagas disease ; Antioxidant properties
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：1 September, 2012
• 年：2012
• 卷：22
• 期：17
• 页码：5569-5573
• 全文大小：538 K

文摘

In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties. We have used the 4-hydroxycoumarin moiety (compound 1) as the molecular template for the synthesis of compounds 2-7. These derivates have shown moderate trypanocidal activity. However they have been proved to be good antioxidants. In particular compound 7 is the most active antioxidant and it is, therefore, a potential candidate for a successful employment in conditions characterized by free radicals overproduction.