Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque

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• 作者：Angela Serena Maione^a ; ¹ ; Ersilia Cipolletta^b ; ¹ ; Daniela Sorriento^h ; Francesco Borriello^a ; ^c ; Maria Soprano^a ; Maria Rosaria Rusciano^a ; Vittoria D'Esposito^a ; Abdul Karim Markabaoui^d ; Giovanni Domenico De Palma^d ; Giovanni Martino^d ; Lucio Maresca^e ; Giuseppe Nobile^e ; Pietro Campiglia^f ; Pietro Formisano^a ; Michele Ciccarelli^b ; Gianni Marone^a ; ^c ; ^g ; Bruno Trimarco^h ; Guido Iaccarino^b ; Maddalena Illario^a ; ⁱ ; ^{illario@unina.it}
• 关键词：Atherosclerosis ; CaMKII ; VSMCs ; Macrophages ; Stable plaques ; Unstable plaques
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：53-61
• 全文大小：1807 K
• 卷排序：256

文摘

CaMKII plays a critical role in the molecular mechanism that regulate atherosclerotic plaque progression. The crosstalk between macrophages and VSMCs is regulated by CaMKII in atherosclerotic lesions. CaMKII levels are increased in stable plaque (SP), while unstable plaque (UnSP) have increased expression of CaMKIV. This study contributes to the understanding of the molecular mechanism underpinning atherosclerotic plaque progression.