Catalytic activity of magnetic Fe₃O₄@Diatomite earth and acetic acid for the N-acylation of sulfonamides

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• 作者：Mohammad Hadi Ghasemi^a ; Elaheh Kowsari^a ; ; Seyed Kiumars Hosseini^b
• 关键词：Diatomite earth ; Glacial acetic acid ; Magnetic Fe3O4 ; N-acylation ; Sulfonamide
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：20 January 2016
• 年：2016
• 卷：57
• 期：3
• 页码：387-391
• 全文大小：3347 K

文摘

The Brønsted and Lewis acidic promoted N-acylation of sulfonamides with acetic anhydride or benzoyl chloride has been achieved using glacial acetic acid and magnetic Fe₃O₄@Diatomite earth. Use of acetic acid as solvent omits the need for organic bases and permits the isolation of products by filtration and precipitation. Additionally, the magnetic composite Fe₃O₄@Diatomite acts as a conjugate proton super acid, enabling the acylation of sulfonamide compounds.