A metabolite of dietary glucosylceramide from pineapples improves the skin barrier function in hairless mice

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• 作者：Takashi Kuwata^a ; Takashi Hashimoto^a ; ^{takashi@kobe-u.ac.jp} ; Nobuaki Ohto^b ; ^{n-ohto@maruzenpcy.co.jp} ; Hiroshige Kuwahara^b ; ^{h-kuwahara@maruzenpcy.co.jp} ; Jae Won Lee^c ; Takeshi Bamba^c ; ^d ; ^{bamba@bioreg.kyushu-u.ac.jp} ; Masashi Mizuno^a ; ^{mizuno@kobe-u.ac.jp}
• 关键词：CBE ; conduritol B epoxide ; D-e-MAPP ; (1S ; 2R-D-erythro-2-N-myristoylamino)-1-phenyl-1-propanol ; GlcCer ; glucosylceramide ; 2-HAA ; 2-hydroxyeicosanoic acid ; HACPT ; 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole ; HR-AD ; unsaturated fatty acids-deficient ; IL ; interleukin ; LPS ; lipopolysaccharide ; P-GlcCer ; pineapple glucosylceramide ; S1P ; sphingosine-1-phosphate ; 4 ; 8-SD ; 48-sphingadienine ; SFC/MS ; supercritical fluid chromatography followed by tandem mass spectrometry ; TEWL ; transepidermal water los
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：228-236
• 全文大小：953 K
• 卷排序：30

文摘

Oral administration of pineapple-glucosylceramide improves skin barrier function. Metabolite of glucosylceramide in small intestine remedies skin barrier function. Enhancement of IL-23 secretion in serum is important to improve skin function.