CaMKIIα knockdown decreases anxiety in the open field and low serotonin-induced upregulation of GluA1 in the basolateral amygdala
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- 作者：Lee Trana ; N. Bradley Keelea ; b ; NB_Keele@baylor.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; AAV ; amygdala ; CaMKII ; Glutamate ; Immunoblot ; RNAi ; RT-PCR
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：303
- 期：Complete
- 页码：152-159
- 全文大小：1479 K
文摘
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Low serotonin (5-HT) increased anxiety and glutamate receptor (GluA1) expression.
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Depletion of 5-HT in the basolateral amygdala (BLA) increased CaMKII activation.
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CaMKII activation correlated with anxiety and GluA1 expression.
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Knockdown of CaMKII in the BLA attenuated anxiety and decreased GluA1 expression.