Molecular basis for the dual subcellular distribution of microsomal glutathione transferase 1

详细信息    查看全文

• 作者：Miyuki Shimoji^a ; Ricardo A. Figueroa^b ; Etienne Neve^a ; Danuta Maksel^b ; ¹ ; Gabriela Imreh^b ; ² ; Ralf Morgenstern^a ; ^{ralf.morgenstern@ki.se} ; Einar Hallberg^b
• 关键词：Subcellular targeting ; Dual distribution ; Glutathione transferase
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1859
• 期：2
• 页码：238-244
• 全文大小：1318 K
• 卷排序：1859

文摘

Microsomal glutathione transferase 1 is targeted to both mitochondria and ER membranes. Microsomal glutathione transferase 1 is co-translationally inserted into ER. A lysine in the first membrane spanning segment (of four) is responsible for dual targeting.