Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition
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- 作者：Steven F. Griecoa ; b ; Yuyan Chenga ; b ; Hagit Eldar-Finkelmanc ; Richard S. Jopea ; b ; Elé ; onore Beurela ; b ; ebeurel@med.miami.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ketamine ; Glycogen synthase kinase-3 ; Insulin-like growth factor 2 ; Depression ; Hippocampus ; Learned helplessness
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2017
- 出版时间：4 January 2017
- 年：2017
- 卷：72
- 期：Complete
- 页码：49-54
- 全文大小：828 K
文摘
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An antidepressant dose of ketamine up-regulates IGF2 in mouse hippocampus
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GSK3 inhibition is necessary and sufficient for up-regulation of IGF2
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Ketamine inhibits activated GSK3 and increases IGF2 expression in depressed mice
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IGF siRNA blocks ketamine's antidepressant efficacy in learned helplessness
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IGF2 levels may differentiate resilient and susceptible mice to learned helplessness