Lucidone Promotes the Cutaneous Wound Healing Process via Activation of the PI₃K/AKT, Wnt/β-catenin and NF-κB Signaling Pathways

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• 作者：Hsin-Ling Yang^a ; Yu-Cheng Tsai^b ; Mallikarjuna Korivi^a ; Chia-Ting Chang^a ; You-Cheng Hseu^b ; ^c ; ^{ychseu@mail.cmu.edu.tw}
• 关键词：CDK ; cyclin dependent kinase ; COX ; cyclooxygenase ; ECM ; extracellular matrix ; EMT ; epithelial-mesenchymal transition ; GSK3β ; glycogen synthase kinase 3 beta ; ICAM ; intercellular adhesion molecule ; iNOS ; inducible nitric oxide synthase ; LY294002 ; (4-morpholinyl)-8-phenyl-4H-l-benzopyran-4-one ; MMPs ; matrix metalloproteinases ; NF-κB ; nuclear factor κB ; PCNA ; proliferating cell nuclear antigen ; PI3K ; phosphatidylinositol 3-kinase ; Tcf/Lcf ; T-cell factor/lymphoid enhancer factor ; TGFβ ; transforming
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1864
• 期：1
• 页码：151-168
• 全文大小：2769 K
• 卷排序：1864

文摘

Lucidone promoted proliferation and migration/invasion of HaCaT and Hs68 cells. Lucidone triggerd β-catenin nuclear translocation, c-Myc/cyclin D1 and cell-cycle. Lucidone-induced PI3K/AKT signaling regulates β-catenin and proliferation/migration. β-catenin knockdown diminished lucidone-induced migration and β-catenin activation. Topical application of lucidone rapidly healed the wounds made on BALB/c mice.