Alterations in the intestine of Patagonian silverside (Odontesthes hatcheri) exposed to microcystin-LR: Changes in the glycosylation pattern of the intestinal wall and inhibition of multidrug resistance proteins efflux activity
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- 作者：Flavia Bieczynskia ; 675.bieczynskif@comahue-conicet.gob.ar" class="auth_mail" title="E-mail the corresponding author ; flabieczynski@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Walter D.C. Torresb ; Julio C. Painefilua ; Juan M. Castroa ; Virginia A. Bianchia ; Jimena L. Fronterad ; Dante A. Pazd ; Carolina Gonzá ; leze ; Alejandro Martí ; ne ; Silvina S.M. Villanuevac ; Carlos M. Luqueta
- 关键词：ABC ; ATP-binding cassette ; Abcb1 ; p-glycoprotein ; Abcc ; multidrug resistance-associated proteins ; Bcrp ; breast cancer resistance protein ; BSA ; bovine seroalbumine ; calcein-AM ; calcein acetoxymethyl ester ; CDNB ; 1-chloro-2 ; 4-dinitrobenzene ; ConA-FITC ; fluorescein labeled Canavalia ensiformis agglutinin ; DBA ; biotinylated-Dolichos biflorus agglutinin ; DNP-SG ; 2 ; 4-dinitrophenyl-S-glutathione ; DTT ; dithiothreitol ; GSH ; reduced glutathione ; GST ; glutathione-S transferase ; GS-X pumps ; ATP-dependent gl
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：178
- 期：Complete
- 页码：106-117
- 全文大小：5380 K
文摘
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O. hatcheri received MCLR through the diet for lectin-histochemistry studies.
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MCLR changed the intestinal epithelium glycoconjugates composition and distribution.
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MCLR transport was studied in ex vivo O. hatcheri’s intestine preparations.
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MCLR inhibited apical and basolateral transport of Abcc substrates (DNP-SG, calcein).
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MCLR would be excreted and/or absorbed to the blood by Abcc proteins.