Terpenes with antimicrobial activity from Cretan propolis

详细信息    查看全文

• 作者：Milena P. Popova ; Ioanna B. Chinou ; Ilko N. Marekov ; Vassya S. Bankova
• 关键词：Cretan propolis ; Diterpenes ; Triterpenes ; Fatty acid diterpenoic esters ; Flavonoid glycoside ; Antimicrobial activity
• 刊名：Phytochemistry
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：70
• 期：10
• 页码：1262-1271
• 全文大小：433 K

文摘

Five terpenes, the diterpenes: 14,15-dinor-13-oxo-8(17)-labden-19-oic acid and a mixture of labda-8(17),13E-dien-19-carboxy-15-yl oleate and palmitate as well as the triterpenes, 3,4-seco-cycloart-12-hydroxy-4(28),24-dien-3-oic acid and cycloart-3,7-dihydroxy-24-en-28-oic acid were isolated from Cretan propolis. Moreover, 18 known compounds were also isolated, seven of them for the first time as propolis components. All structures were established on the basis of spectroscopic analysis and chemical evidence. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against some human pathogenic fungi showing a broad spectrum of antimicrobial activity.