Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative
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- 作者：Norbert Nassa ; norbert.nass@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Saadettin Selb ; Atanas Ignatovc ; Albert Roessnera ; Thomas Kalinskia
- 关键词：Glyoxal ; Methylglyoxal ; Glyoxalase ; MAP-kinase signaling ; Protein kinase B (AKT) ; NF-κB ; Reactive oxygen species (ROS)
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1272-1280
- 全文大小：2181 K
文摘
- istitem" id="list_l0005">
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id="p0005">Dicarbonyls evoke oxidative stress in mamma carcinoma cells.
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id="p0010">Dicarbonlys activate NADPH-oxidase via p38 MAPK.
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id="p0015">Dicarbonlys activate p42/44 MAPK,PKB and NF-κB via independent pathways.
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id="p0020">Glyoxalase I activity is essential for dicarbonyl resistance.
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id="p0025">Glyoxalase I mRNA abundance is a prognostic marker for estrogen receptor positive breast carcinoma.