Controlling silica coating thickness on TiO₂ nanoparticles for effective photodynamic therapy

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• 作者：Xiaohui Feng^a ; ¹ ; Shaokun Zhang^b ; ¹ ; Xia Lou^a ; ^{X.Lou@curtin.edu.au} ; ^{lizilou7854@gmail.com}
• 关键词：Silica-coated TiO2 nanoparticles ; Silica coating ; TiO2 nanoparticles ; Photo-killing agent ; Photodynamic therapy
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2013
• 出版时间：1 July, 2013
• 年：2013
• 卷：107
• 期：Complete
• 页码：220-226
• 全文大小：1491 K

文摘

Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy. In this paper, core-shell structured titanium dioxide-silica (TiO₂-SiO₂) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicity and photo-killing ability of the TiO₂ nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO₂ nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5 nm, the coated TiO₂ not only retained a high level photodynamic reactivity, comparable to the non-coated TiO₂ nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929).