From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo
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- 作者：Imran Alia ; 2 ; imran.ali@ki.se" class="auth_mail" title="E-mail the corresponding author ; Teija Hurmerintab ; 2 ; Tarja Nurmic ; Marika Berglunda ; Joelle Rü ; eggd ; e ; Matti Poutanenf ; g ; Krister Halldina ; Sari Mä ; kelä ; b ; g ; Pauliina Damdimopouloub ; 1
- 关键词：ADME ; absorption ; distribution ; metabolism and excretion ; bw ; body weight ; E2 ; 17β-estradiol ; EDC ; endocrine disruptive chemical ; EGFR ; epidermal growth factor receptor ; ERE ; estrogen response element ; ERE-luc ; ERE-luciferase ; GNX ; gonadiectomized ; LUMA ; luminometric methylation assay ; MAPK ; mitogen activated protein kinase ; NOEL ; no observed effect level ; OVX ; ovariectomized ; RLU ; relative light units
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：24 June 2016
- 年：2016
- 卷：253
- 期：Complete
- 页码：27-35
- 全文大小：1300 K
文摘
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Endocrine activity of diet-bound cadmium and lignans at human relevant exposure.
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Diet rich in cadmium activates EGFR-MAPK signalling as predicted by CdCl2 exposure studies.
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Enterolactone is an estrogen modulator as pure compound but not in dietary exposure.
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Dietary and pure compound exposure can be compared in controlled settings in vivo.