Metaplastic carcinoma of the breast with neuroglial differentiation

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• 作者：Mehra Golshan ; Adam Kuten ; Jacquleine William ; Andrea Richardson ; Amir Modarressi ; Ursula Matulonis
• 关键词：Metaplastic carcinoma ; Neuroglial differentiation ; Neoadjuvant chemotherapy
• 刊名：The Breast
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：15
• 期：4
• 页码：545-549
• 全文大小：597 K

文摘

We present a case of a 34-year-old female who had a rapidly enlarging right breast mass. Biopsy results were consistent with a neuroblastic neoplasm of the breast. Neoadjuvant chemotherapy for a neuroblastoma was performed followed by a modified radical mastectomy was performed. Final pathology revealed small foci of poorly differentiated carcinoma randomly distributed within extensive areas of neuroglial differentiation. Such a lesion has not been described in the current literature to our knowledge, and we propose that this neoplasm is a metaplastic carcinoma with a novel heterogeneous differentiation. Subsequent therapy consisted of standard adjuvant breast cancer chemotherapy and radiation therapy.