Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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• 作者：Silvie Timmers¹ ;   ; ² ;   ; ⁸ ; Ellen Konings² ;   ; ⁸ ; Lena Bilet² ; Riekelt  ; H. Houtkooper⁵ ; Tineke van  ; de  ; Weijer² ; Gijs  ; H. Goossens² ; Joris Hoeks² ; Sophie van  ; der  ; Krieken² ; Dongryeol Ryu⁵ ; Sander Kersten⁶ ; Esther Moonen-Kornips² ; Matthijs  ; K.C. Hesselink³ ; Iris Kunz⁷ ; Vera  ; B. Schrauwen-Hinderling⁴ ; Ellen E. Blaak² ; Johan Auwerx⁵ ; Patrick Schrauwen¹ ;   ; ² ;   ; ^{p.schrauwen@maastrichtuniversity.nl}
• 刊名：Cell Metabolism
• 出版年：2011
• 出版时间：2 November 2011
• 年：2011
• 卷：14
• 期：5
• 页码：612-622
• 全文大小：952 K

文摘

Summary

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150?mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30?days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1¦Á protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30?days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.