d-Govadine facilitates the rate of extinction of amphetamine CPP when administered either during the conditioning or extinction phase. d-Govadine blocks the acquisition of food CPP when administered during the conditioning phase. d-Govadine blocks the amphetamine-induced reinstatement of amphetamine CPP. These effects suggest that d-govadine may have differential effects on the acquisition of conditioned associations and extinction learning, and has broad effects on the reward-context associations.