Selection of HIV vaccine candidates for concurrent testing in an efficacy trial
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- 作者：Ying Huang1 ; yhuang@fhcrc.org" class="auth_mail" title="E-mail the corresponding author ; Carlos DiazGranados2 ; Holly Janes1 ; Yunda Huang1 ; Allan C deCamp1 ; Barbara Metch1 ; Shannon Grant1 ; Brittany Sanchez1 ; Sanjay Phogat2 ; Marguerite Koutsoukos3 ; Niranjan Kanesa-Thasan3 ; Patricia Bourguignon3 ; Alix Collard3 ; Susan Buchbinder4 ; Georgia D Tomaras5 ; Julie McElrath1 ; Glenda Gray6 ; James G Kublin1 ; Lawrence Corey1 ; Peter B Gilbert1 ; pgilbert@fhcrc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Virology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：17
- 期：Complete
- 页码：57-65
- 全文大小：745 K
文摘
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Selection of more than 1 regimen would lead to the first multi-regimen HIV vaccine efficacy trial.
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Choices of immune correlates for down-selection are both knowledge-based and comprehensive.
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The approach has good performance to differentiate medium to large immunological differences.
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